Interventional closure of RPA-to-LA communication in an oligosymptomatic neonate

Direct communication between the right pulmonary artery (RPA) and the left atrium (LA) is a very rare cardiac malformation. Clinical presentation of RPA-to-LA communication depends on the size of the communication, the amount of right-to-left shunt, the patient’s age, and pulmonary vascular resistance. Patients with small communications usually present oligosymptomatic and are diagnosed at an older age. A delay of diagnosis bears the risk of severe complications and needs to be prevented by proper work-up of oligosymptomatic neonates. Treatment of RPA-to-LA communications used to be performed by surgical closure, and the interventional approach has only been established as a less invasive alternative in recent years. Conclusion: Although patients with small RPA-to-LA communications usually present oligosymptomatic, early diagnosis and treatment is essential to prevent life-threatening complications

Analyzing Tag Semantics Across Collaborative Tagging Systems

The objective of our group was to exploit state-of-the-art Information Retrieval methods for finding associations and dependencies between tags, capturing and representing differences in tagging behavior and vocabulary of various folksonomies, with the overall aim to better understand the semantics of tags and the tagging process. Therefore we analyze the semantic content of tags in the Flickr and Delicious folksonomies. We find that: tag context similarity leads to meaningful results in Flickr, despite its narrow folksonomy character; the comparison of tags across Flickr and Delicious shows little semantic overlap, being tags in Flickr associated more to visual aspects rather than technological as it seems to be in Delicious; there are regions in the tag-tag space, provided with the cosine similarity metric, that are characterized by high density; the order of tags inside a post has a semantic relevance

Community Assessment using Evidence Networks

Abstract. Community mining is a prominent approach for identifying (user) communities in social and ubiquitous contexts. While there are a variety of methods for community mining and detection, the effective evaluation and validation of the mined communities is usually non-trivial. Often there is no evaluation data at hand in order to validate the discovered groups. This paper proposes evidence networks using implicit information for the evaluation of communities. The presented evaluation approach is based on the idea of reconstructing existing social structures for the assessment and evaluation of a given clustering. We analyze and compare the presented evidence networks using user data from the real-world social bookmarking application BibSonomy. The results indicate that the evidence networks reflect the relative rating of the explicit ones very well.

Collisions between equal sized ice grain agglomerates

Following the recent insight in the material structure of comets, protoplanetesimals are assumed to have low densities and to be highly porous agglomerates. It is still unclear if planetesimals can be formed from these objects by collisional growth. Therefore, it is important to study numerically the collisional outcome from low velocity impacts of equal sized porous agglomerates which are too large to be examined in a laboratory experiment. We use the Lagrangian particle method Smooth Particle Hydrodynamics to solve the equations that describe the dynamics of elastic and plastic bodies. Additionally, to account for the influence of porosity, we follow a previous developed equation of state and certain relations between the material strength and the relative density. Collisional growth seems possible for rather low collision velocities and particular material strengths. The remnants of collisions with impact parameters that are larger than 50% of the radius of the colliding objects tend to rotate. For small impact parameters, the colliding objects are effectively slowed down without a prominent compaction of the porous structure, which probably increases the possibility for growth. The protoplanetesimals, however, do not stick together for the most part of the employed material strengths. An important issue in subsequent studies has to be the influence of rotation to collisional growth. Moreover, for realistic simulations of protoplanetesimals it is crucial to know the correct material parameters in more detail.Comment: 7 pages, 11 figures, accepted by A&

The Calpain, Caspase 12, Caspase 3 Cascade Leading to Apoptosis Is Altered in F508del-CFTR Expressing Cells

In cystic fibrosis (CF), the most frequent mutant variant of the cystic fibrosis transmembrane conductance regulator (CFTR), F508del-CFTR protein, is misfolded and retained in the endoplasmic reticulum (ER). We previously showed that the unfolded protein response (UPR) may be triggered in CF. Since prolonged UPR activation leads to apoptosis via the calcium-calpain-caspase-12-caspase-3 cascade and because apoptosis is altered in CF, our aim was to compare the ER stress-induced apoptosis pathway between wild type (Wt) and F508del-CFTR expressing cells. Here we show that the calcium-calpain-caspase-12-caspase-3 cascade is altered in F508del-CFTR expressing cells. We propose that this alteration is involved in the altered apoptosis triggering observed in CF

Interventional closure of RPA-to-LA communication in an oligosymptomatic neonate

Direct communication between the right pulmonary artery (RPA) and the left atrium (LA) is a very rare cardiac malformation. Clinical presentation of RPA-to-LA communication depends on the size of the communication, the amount of right-to-left shunt, the patient's age, and pulmonary vascular resistance. Patients with small communications usually present oligosymptomatic and are diagnosed at an older age. A delay of diagnosis bears the risk of severe complications and needs to be prevented by proper work-up of oligosymptomatic neonates. Treatment of RPA-to-LA communications used to be performed by surgical closure, and the interventional approach has only been established as a less invasive alternative in recent years. Conclusion: Although patients with small RPA-to-LA communications usually present oligosymptomatic, early diagnosis and treatment is essential to prevent life-threatening complications